Bipolar Spectrum Bipolar I - major depression and mania Bipolar II - major depression and hypomania Bipolar III - mild depression and hypomania (cyclothymia) Bipolar IV - depression and usually no mania (but antidepressants can trigger mania) Bipolar V - depression and no mania but mania in blood relatives (use medication that works for the relatives) Bipolar VI - mania and no depression - rare